PhD Project ESR6


Development of inhibitors of Tau aggregation

SUPERVISORS

Prof. Sandrine Ongeri, University of Paris Sud

Prof. Maria Luisa Gelmi, University of Milan (secondment)

INVOLVED UNIVERSITIES

University of Paris Sud (recruitment process and hosting)

University of Milan

INVOLED COMPANY

PhD COURSES

Pharmaceutical Sciences (UNIMI)
Therapeutic Innovation (UPSud)

OBJECTIVES

Design, synthesis, biophysical and biochemical evaluation of peptides and peptidomimetics as ligands of Tau in order to modulate its aggregation.

DESCRIPTION OF THE PROJECT 

The Early Stage researcher (ESR) will synthesize mimics of β-strands and β-hairpins bearing specific sequences selected from Tau and involved in the aggregation. He/She will be involved in the synthesis of unnatural scaffolds, i.e. non-natural AAs and/or turn mimics from the library available at UMIL, or new scaffolds (fluorinated and or fluorescent), according to the results of the computational design. He/She will perform conformational studies using NMR techniques and will be involved in the biophysical and biochemical evaluations of the activity of compounds on Tau aggregation (ThT fluorescence spectroscopy, Microscopy, Capillary electrophoresis).

The ESR will be enrolled by the University of Paris Saclay (https://www.universite-paris-saclay.fr/en) under the supervision of Prof. Sandrine Ongeri and will be awarded a Double Doctorate degree in co-tutelle with the University of Milano (https://www.unimi.it/), Italy, under the supervision of Prof. Maria Luisa Gelmi.

The research will involve 12 months secondments at the University of Milan (synthesis of non-natural AAs and/or turn mimics) and 3 months secondments in cell microscopy and super-resolution, at San Raffaele Hospital (https://research.hsr.it/en/index.html, Cent. di Imaging Sperimentale,) under the supervision of Dr. Davide Mazza.

The selected candidate will participate in the network’s training activities.

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